Clinical exacerbation of SARS‐CoV2 infection after fingolimod withdrawal
نویسندگان
چکیده
منابع مشابه
Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment.
BACKGROUND The oral sphingosine-1-phosphate receptor modulator fingolimod (FTY720) was recently approved for the treatment of relapsing-remitting multiple sclerosis. To date, data about a possible recurrence of disease activity after discontinuation of fingolimod treatment are scarce. OBJECTIVE To describe a patient who discontinued fingolimod treatment after a local malignant melanoma was di...
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Rebound disease following cessation of disease modifying treatment (DMT) has been reported in people with both relapsing and progressive multiple sclerosis (pwRMS, pwPMS) questioning strict separation between these two phenotypes. While licensed DMT is available for pwRMS to counter rebound disease, no such option exists for pwPMS. We report on a pwPMS who developed rebound disease, with 45 Gad...
متن کاملDramatic rebounds of MS during pregnancy following fingolimod withdrawal
In MS, discontinuation of some therapies may result in a transitory, possibly overwhelming, increase in disease activity. We report 2 cases of severe clinical rebound after fingolimod suspension occurring in 2 patients following pregnancy. Clinical rebound was defined as the occurrence of new severe neurologic symptoms together with a significant increase of new or enlarging T2-weighted or gado...
متن کاملSevere multiple sclerosis reactivation under fingolimod 3 months after natalizumab withdrawal.
We report the case of a woman with multiple sclerosis who developed a severe neurological condition following natalizumab (NZB) withdrawal and soon after fingolimod (FTY) initiation. FTY was started 3.5 months after a two-year NZB treatment. Fifteen days later, she suffered partial repetitive seizures followed by a tonicoclonic seizure. This was associated with attention difficulties and an inc...
متن کاملTuberculosis Infection Among Medical Students before and After Clinical Rotations
Abstract Introduction: Considering the importance of screening for diagnosis of tuberculosis (TB) infection among medical students and the necessity of annual TB tests and effectiveness of preventive programs, there is an ever increasing need for undertaking research to investigate the effect of residence in hospital on the risk of tuberculosis infection among students, and planning strategies...
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ژورنال
عنوان ژورنال: Journal of Medical Virology
سال: 2020
ISSN: 0146-6615,1096-9071
DOI: 10.1002/jmv.26279